Fa parte del modulo variabile. S’utilizza in dosi di 1 g ai pasti due volte al giorno.

Caratteristiche Farmacologiche:
Secondo l’insegnamento del Prof Di Bella, la calcemia nei malati neoplastici andrebbe mantenuta tra 9 e 9,50 milligrammi /100 di plasma, senza superare i 10. Sarebbe opportuno determinare le tre frazioni plasmatiche del calcio: il calcio molecolare, colloidale e ionico. Si utilizza in dosi di 1 g ai pasti due volte al giorno, unitamente all’acido ascorbico che ne facilita l’assimilazione. È un minerale utilizzato per la sua funzione metabolica e l’attività sul trofismo osseo, sui tessuti mesenchimali e la regolazione di aspetti vitali dell’attività cellulare. È particolarmente indicato nelle patologie gastro-intestinali, mesenchimali ed ossee in sinergismo con la vitamina D3. Il calcio intracellulare gioca un ruolo importante nella divisione cellulare, e la sintesi del DNA è attivata dall’incremento della sua concentrazione intracellulare. Interferisce con la sintesi della prostaglandina; livelli elevati intracellulari di calcio possono attivare la crescita neoplastica. Si può considerare pertanto il calcio un rilevante meccanismo segnaletico della differenziazione, proliferazione, involuzione neoplastica cellulare. È anche un elemento fondamentale della comunicazione intercellulare e della matrice extracellulare. Decisivo il suo ruolo nei meccanismi apoptotici.

Documenti Scientifici associati
(per visualizzarne il contenuto è sufficiente collegarsi alla Banca Dati PubMed (clicca quì) riportando, con un semplice copia/incolla, il titolo della singola pubblicazione nell’apposita stringa di ricerca.)
Anti-cancer drugs interfere with intracellular calcium signaling.
Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study.
A case of cT0N2M0 small cell lung cancer with Lambert-Eaton myasthenic syndrome
A case of disseminated tumor from cecal cancer with survival for over 5 years after twice surgical resection and systemic chemotherapy
A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results.
A novel mechanism underlying phytate-mediated biological action-phytate hydrolysates induce intracellular calcium signaling by a Gαq protein-coupled receptor and phospholipase C-dependent mechanism in colorectal cancer cells.
A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells.
A short primer on the calcium sensing receptor: an important cog in the colon cancer wheel?
A synthetic 15-mer peptide (PCK3145) derived from prostate secretory protein can reduce tumor growth, experimental skeletal metastases, and malignancy-associated hypercalcemia.
Adjuvant chemotherapy for unresectable locally advanced pancreatic cancer in light of its characteristics.
Altered calcium metabolism in patients on long-term bisphosphonate therapy for
Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.
Association between vitamin D and calcium intake and breast cancer risk according to menopausal status and receptor status in Japan.
Bone health and aging: implications for menopause.
Bone mineral density in women receiving thyroxine suppressive therapy for differentiated thyroid carcinoma.
Breast cancer and concomitant primary hyperparathyroidism: description of two patients.
Calcium and vitamin D modulate mouse colon epithelial proliferation and growth characteristics of a human colon tumor cell line.
Calcium intake and colorectal adenoma in a US colorectal cancer early detection program.
Calcium sensing receptor down-regulates malignant cell behavior and promotes chemosensitivity in human breast cancer cells.
Calcium signals and cancer.
Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma.
Calcium supplementation for preventing colorectal cancer: where do we stand?
Calcium wave signaling in cancer cells.
Calcium, calcium-sensing receptor and colon cancer.
Calcium, inorganic phosphates, alkaline and acid phosphatase activities in breast cancer patients in Calabar, Nigeria.
Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells.
Calcium/calmodulin-dependent kinase II regulates notch-1 signaling in prostate cancer cells.
Chemoprevention of colorectal cancer.
Chemoprevention of colorectal cancer: an update.
Collagen and calcium-binding EGF domains 1 is frequently inactivated in ovarian cancer by aberrant promoter hypermethylation and modulates cell migration and survival.
Colorectal cancer prevention.
Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies.
Comparison of fracture, cardiovascular event, and breast cancer rates at 3 years in postmenopausal women with osteoporosis.
Control of cell division: a unifying hypothesis.
Dairy consumption and calcium intake and risk of breast cancer in a prospective cohort: the Norwegian Women and Cancer study.
Dairy food, calcium, and risk of cancer in the NIH-AARP Diet and Health Study.
Deferral of coronary intervention based on measurement of myocardial fractional flow reserve.
Does dietary calcium supplementation reduce the risk of colon cancer?
Dysphagia after total laryngectomy resulting from hypocalcemia: case report.
Effect of anticoagulants on remote results after surgical treatment of patients with colon cancer depending on tumor growth and differentiation
Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer.
Effectiveness of 1alpha-hydroxyvitamin D2 in inhibiting tumor growth in a murine transgenic pigmented ocular tumor model.
Effectiveness of vitamin D analogues in treating large tumors and during prolonged use in murine retinoblastoma models.
Effects of clodronate on cancer growth and Ca2+ signaling of human thyroid carcinoma cell lines.
Effects of tamoxifen on bone mineral density and metabolism in postmenopausal women with early-stage breast cancer.
Enhanced S100 calcium-binding protein P expression sensitizes human bladder cancer cells
Evaluation of kidney damage in patients with acute lymphoblastic leukemia in long-term follow-up: value of renal scan.
Expression of P2X7 in human hematopoietic cell lines and leukemia patients.
Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer.
First report of a vincristine dose-related Raynaud's phenomenon in an adolescent with malignant brain tumor.
Follow-up results of treatment of gastric cancer concerning the tumor spreading in application of antihemostatic preparations.
Generation of a humanized monoclonal antibody against human parathyroid hormone-related protein and its efficacy against humoral hypercalcemia of malignancy.
Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry.
Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator
Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089.
HIF-1alpha and calcium signaling as targets for treatment of prostate cancer by cardiac glycosides.
Hot flashes in breast cancer survivors and an association with calcium supplement use.
Human studies of calcium supplementation and colorectal epithelial cell proliferation.
Hypercalcemia and Childhood Cancer: A 7-Year Experience.
Il Metodo Di Bella (relazione al Congr.Mondiale di Singapore)
In vitro assessment of decellularized porcine dermis as a matrix for urinary tract reconstruction.
Incidence and pathogenesis of tumor lysis syndrome.
Increase in cytosolic calcium maintains plasma membrane integrity through the formation of microtubule ring structure in apoptotic cervical cancer cells induced by trichosanthin.
Independent and joint effects of serum 25-hydroxyvitamin D and calcium on ovarian cancer risk: a prospective nested case-control study.
Induction in myeloid leukemic cells of genes that are expressed in different normal tissues.
Inhibition of calcium-independent phospholipase A2 activates p38 MAPK signaling pathways during cytostasis in prostate cancer cells.
Intracellular signaling mechanisms in photodynamic therapy. Biochim Biophys Acta.
Intravenous calcium and magnesium for oxaliplatin-induced sensory neurotoxicity in adjuvant colon cancer: NCCTG N04C7.
Is the treatment of Hodgkin's disease detrimental to the parathyroid gland?
L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines.
Levonorgestrel and 17beta-estradiol given transdermally for the prevention of postmenopausal osteoporosis.
Long-term dietary calcium intake and breast cancer risk in a prospective cohort of women.
Long-term follow-up of patients with elevated PTH levels following successful exploration for primary hyperparathyroidism.
Magnesium, calcium and cancer.
Meta-analysis of vitamin D, calcium and the prevention of breast cancer.
Misclassification of exposure is high when interview data on drug use are used as a proxy measure of chronic drug use during follow-up.
Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells.
Modulation of calcium by the carcinogenic process in the liver induced by a choline-deficient diet.
NADPH oxidase-mediated generation of reactive oxygen species is critically required for survival of undifferentiated human promyelocytic leukemia cell line HL-60.
Nanosecond pulsed electric fields modulate cell function through intracellular signal transduction mechanisms.
Neuroblastoma angiogenesis is inhibited with a folded synthetic molecule corresponding to the epidermal growth factor-like module of the follistatin domain of SPARC.
Nordihydroguaiaretic acid-induced Ca2+ handling and cytotoxicity in human prostate cancer cells
Oral signs of intravenous chemotherapy with 5-Fluorouracil and Leucovorin calcium in colon cancer treatment.
Osteoporosis and obesity in men receiving hormone therapy for prostate cancer.
Parathyroid carcinoma: a 22-year experience.
Physician practices of bone density testing and drug prescribing to prevent or treat osteoporosis during androgen deprivation therapy.
Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human
Prognostic significance of disordered calcium metabolism in hormone-refractory prostate cancer patients with metastatic bone disease.
Quality of life of well-differentiated thyroid carcinoma patients.
Randomized controlled trial of pelvic calcium alginate following rectal cancer surgery.
Randomized trial of the effect of calcium supplementation on fecal risk factors for colorectal cancer.
Randomized, double-blinded, placebo-controlled intervention study with supplemental calcium in families with hereditary nonpolyposis colorectal cancer.
Regulation of PSA secretion and survival signaling by calcium-independent phopholipase A(2)beta in prostate cancer cells.
Repeated surgeries in primary hyperparathyroidism
Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA.
Review article: chemoprevention of colorectal cancer.
Risposta obiettiva completa a terapia biologica di carcinoma plurifocale della mammella
Role of calcium/ magnesium infusion in oxaliplatin-based chemotherapy for colorectal cancer patients.
Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer.
Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma.
Serum Calcium Is Not Predictive of Aggressive Prostate Cancer After Radical
Serum calcium and breast cancer risk in a prospective cohort study.
Serum calcium and the risk of prostate cancer.
Serum levels of vitamin D, PTH and calcium and breast cancer risk-a prospective nested
Severe primary hyperparathyroidism and vitamin D deficiency.
Should calcium and vitamin D be added to the current enrichment program for cereal-grain products?
Simvastatin induces death of multiple myeloma cell lines.
Skeletal morbidity in men with prostate cancer: quality-of-life considerations throughout the continuum of care.
Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells.
Strategies for prevention of colorectal cancer: pharmaceutical and nutritional interventions.
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.
Supplemental calcium in the chemoprevention of colorectal cancer: a systematic review and meta-analysis.
Systematic review of bisphosphonates for hypercalcaemia of malignancy.
Tamoxifen down-regulates CaMKII messenger RNA levels in normal human breast tissue.
Taxol directly induces endoplasmic reticulum-associated calcium changes that promote apoptosis in breast cancer cells.
The biology of CD20 and its potential as a target for mAb therapy.
The diagnosis and treatment of osteoporosis in men on androgen deprivation therapy for advanced carcinoma of the prostate.
The effect of calcium and vitamin supplements on the incidence and recurrence of colorectal adenomatous polyps.
The effect of prophylactic calcium and magnesium infusions on the incidence of neurotoxicity and clinical outcome of oxaliplatin-based systemic treatment in advanced colorectal cancer patients.
The influence of androgen deprivation therapy on metabolism in patients with prostate cancer.
The platinum (II) complex [Pt(O,O'-acac)(γ-acac)(DMS)] alters the intracellular calcium homeostasis in MCF-7 breast cancer cells.
The positive control of cell proliferation by the interplay on calcium ions and cyclic nucleotides. A review.
Thymic squamous cell carcinoma producing parathyroid hormone-related protein and CYFRA 21-1.
Tissue distribution and activity studies of 1,24-dihydroxyvitamin D2, a metabolite of vitamin D2 with low calcemic activity in vivo.
Toxicity and antineoplastic effect of (24R)-1,24-dihydroxyvitamin D3 (PRI-2191).
Treating cancer-related hypercalcemia with gallium nitrate.
Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent kinase 5 and consequent onset of the terminal phase of HL60 cell differentiation.
Up-to-date on parathyroid carcinoma: analysis of an experience of 19 cases.
Upregulation of soluble resistance-related calcium-binding protein (sorcin) in gastric cancer.
Use of calcium phosphate cement for bone defect after harvesting radial forearm osteocutaneous flap.
Vascular endothelial growth factor-C siRNA delivered via calcium carbonate nanoparticle effectively inhibits lymphangiogenesis and growth of colorectal cancer in vivo.
Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women.
Vitamin D and colon carcinogenesis.
Vitamin D and skin cancer.
Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations.
Vocal fold augmentation with calcium hydroxylapatite.
[Management of serum calcium with cinacelet in parathyroid cancer].
[Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome associated with anti P/Q-type voltage-gated calcium channel antibody in a patient with primary double lung cancer].
[Selective Expression of Calcium-Binding Protein S100A7 in Lung Cancer.].

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